Taurine supplementation enhances the body’s insulin as well as glucose metabolism, physiologists from the specify university of Campinas report in the Journal of Nutritional Biochemistry. In mice, taurine boosts the secretion of insulin as well as boosts the sensitivity of the insulin receptor in muscles. Taurine may be even a lot more fascinating for athletes than we already thought.
Taurine supplementation enhances the body’s insulin as well as glucose metabolism, physiologists from the specify university of Campinas report in the Journal of Nutritional Biochemistry. In mice, taurine boosts the secretion of insulin as well as boosts the sensitivity of the insulin receptor in muscles. Taurine may be even a lot more fascinating for athletes than we already thought.
At very first sight it looks as though the Brazilian research study is only of rate of interest as a piece of essential research. The researchers provided their lab animals taurine in their food in such big quantities that the human equivalent would be an irresponsibly high amount: 20-22 g taurine per day. however the researchers likewise did experiments in which they taken a look at the impacts of much lower doses of taurine on the insulin metabolism.
The figure below shows the impact of intravenous administration of glucose on glucose levels. Black circles/squares: mice provided exorbitant quantities of taurine in their food. White circles/squares: mice provided feed consisting of no taurine.
In the figure on the left the mice were provided a single intravenous dose of glucose; in the figure on the ideal the mice were provided a single intravenous dose of taurine as well as glucose.
Mice that were provided taurine in their food were much better able to offer with glucose than the mice that were not provided taurine. What worked even much better was simultaneous administration of glucose as well as taurine.
The amount of taurine that the researchers administered together with the glucose was not so high. If you convert the amount for an adult guy weighing 80 kg you’d get 1.6 g. The oral equivalent would not be a lot more than twice this amount.
In a similar experiment the researchers taken a look at the impact of taurine on the working of the insulin receptor. The researchers provided the mice insulin, taurine or a saline option [Sal], as well as then monitored the activity of the insulin receptor. below left: the impact on the insulin receptor in the muscles. below right: the impact on the receptor in the liver.
The taurine dose was about the exact same as in the previously explained experiment.
Taurine may well be an fascinating compound for athletes wanting to pump a lot more glucose into their muscles during training or competitions. Endurance athletes may do much better in this method as well as recuperate faster.
One issue is the timing. Taken orally, taurine is an very ‘slow’ nutrient in humans. If you take taurine it can take as much as two hours for the compound to go into the bloodstream.
Taurine supplementation modulates glucose homeostasis as well as islet function.
Carneiro EM, Latorraca MQ, Araujo E, Beltrá M, Oliveras MJ, Navarro M, Berná G, Bedoya FJ, Velloso LA, Soria B, Martín F.
Abstract
Taurine is a conditionally important amino acid for human that is included in the manage of glucose homeostasis; however, the mechanisms by which the amino acid impacts blood glucose levels are unknown. utilizing an animal model, we have examined these mechanisms. Mice were supplemented with taurine for 30 d. Blood glucose homeostasis was examined by intraperitoneal glucose tolerance tests (IPGTT). Islet cell function was figured out by insulin secretion, cytosolic Ca2+ measurements as well as glucose metabolism from isolated islets. Islet cell gene expression as well as translocation was taken a look at by means of immunohistochemistry as well as quantitative real-time polymerase chain reaction. Insulin signaling was examined by Western blot. Islets from taurine-supplemented mice had: (i) substantially higher insulin content, (ii) boosted insulin secretion at stimulatory glucose concentrations, (iii) substantially displaced the dose-response curve for glucose-induced insulin release to the left, (iv) boosted glucose metabolism at 5.6 as well as 11.1-mmol/L concentrations; (v) slowed cytosolic Ca2+ concentration ([Ca2+]i) oscillations in action to stimulatory glucose concentrations; (vi) boosted insulin, sulfonylurea receptor-1, glucokinase, Glut-2, proconvertase as well as pancreas duodenum homeobox-1 (PDX-1) gene expression as well as (vii) boosted PDX-1 expression in the nucleus. Moreover, taurine supplementation substantially boosted both basal as well as insulin stimulated tyrosine phosphorylation of the insulin receptor in skeletal muscle mass as well as liver tissues. Finally, taurine supplemented mice showed an improved IPGTT. These results suggest that taurine controls glucose homeostasis by regulating the expression of genes needed for glucose-stimulated insulin secretion. In addition, taurine improves peripheral insulin sensitivity.
PMID: 18708284 [PubMed – indexed for MEDLINE]
Source: